High-speed recording of neural spikes in awake mice and flies with a fluorescent voltage sensor
Abstract
Neuroscientists have long sought tools that allow optical imaging of individual neurons' membrane voltage dynamics in awake behaving animals. Gong et al. genetically engineered a protein voltage indicator that can report action potentials with <1-ms precision and orders of magnitude lower spike detection error rates than were previously possible. They were thus able to record action potentials and membrane voltage dynamics in the brains of awake mice and fruit flies.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 11, 2015
- Source ID
- 10.1126/science.aab0810
Entities
People
- Benjamin F. Grewe
- Cheng Huang
- Jin Zhong Li
- Mark Schnitzer
- Stephan Eismann
- Yanping Zhang
- Yiyang Gong
Organizations
- Defense Advanced Research Projects Agency
- Duke University
- National Institutes of Health
- Stanford University