Dengue viruses cluster antigenically but not as discrete serotypes
Abstract
Along with their mosquito vectors, dengue viruses are spreading worldwide to infect millions of people. For a few, subsequent infection results in lethal hemorrhagic disease. Katzelnick et al. used antibody-binding data to map structural divergence and antigenic variation among dengue viruses. Comparing results in monkeys and humans, the viruses approximately clustered into the four known groups. However, the four virus groups showed as much antigenic distance within a group as between groups. This finding helps explain why immune responses to dengue are highly variable, and it has complex implications for epidemiology, disease, and vaccine deployment.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 18, 2015
- Source ID
- 10.1126/science.aac5017
Entities
People
- Albert D.m.e. Osterhaus
- Angela Green
- Anna Durbin
- Cameron P. Simmons
- Chunling Wang
- Colin A. Russell
- Derek J Smith
- Edward C. Holmes
- Eva Harris
- Gregory D. Gromowski
- Hlaing Myat Thu
- John G. Aaskov
- Jorge L. Muñoz-jordán
- Jose Bustos Arriaga
- Judith M. Fonville
- Laura A. VanBlargan
- Leah C Katzelnick
- Louis Lau
- Magelda Montoya
- Nikos Vasilakis
- Philippe Buchy
- Robert B. Tesh
- Robert V Gibbons
- Ron Fouchier
- Sarah L. James
- Stephen S Whitehead
- Theodore C. Pierson
Organizations
- Armed Forces Research Institute of Medical Sciences
- Centers for Disease Control and Prevention
- Department of Medical Research (Myanmar)
- Erasmus MC
- Gates Foundation
- Human Frontier Science Program
- Johns Hopkins Bloomberg School of Public Health
- Medical Research Council
- National Health and Medical Research Council
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- Pasteur Institute
- Queensland University of Technology
- Seventh Framework Programme
- University of California
- University of Cambridge
- University of Melbourne
- University of Oxford
- University of Sydney
- University of Texas Medical Branch
- World Health Organization