Genetic circuit design automation
Abstract
As synthetic biology techniques become more powerful, researchers are anticipating a future in which the design of biological circuits will be similar to the design of integrated circuits in electronics. Nielsen et al. describe what is essentially a programming language to design computational circuits in living cells. The circuits generated on plasmids expressed in Escherichia coli required careful insulation from their genetic context, but primarily functioned as specified. The circuits could, for example, regulate cellular functions in response to multiple environmental signals. Such a strategy can facilitate the development of more complex circuits by genetic engineering.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2016
- Source ID
- 10.1126/science.aac7341
Entities
People
- Alec A K Nielsen
- Bryan S. Der
- Christopher Voigt
- David Ross
- Douglas Densmore
- Elizabeth A. Strychalski
- Jonghyeon Shin
- Prashant Vaidyanathan
- Vanya Paralanov
Organizations
- Air Force Office of Scientific Research
- Boston University
- Massachusetts Institute of Technology
- National Institute of General Medical Sciences
- National Institute of Standards and Technology
- National Research Council
- National Science Foundation
- Office of Naval Research