Nuclear envelope rupture and repair during cancer cell migration
Abstract
The nuclear envelope segregates genomic DNA from the cytoplasm and regulates protein trafficking between the cytosol and the nucleus. Maintaining nuclear envelope integrity during interphase is considered crucial. However, Raab et al. and Denais et al. show that migrating immune and cancer cells experience frequent and transitory nuclear envelope ruptures when they move through tight spaces (see the Perspective by Burke). The nuclear envelope reseals rapidly during interphase, assisted by components of the ESCRT III membrane-remodeling machinery.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 15, 2016
- Source ID
- 10.1126/science.aad7297
Entities
People
- Alexandra L. Mcgregor
- Bettina Weigelin
- Celine M. Denais
- Jan Lammerding
- Katarina Wolf
- Mariska Te Lindert
- Patricia M Davidson
- Peter Friedl
- Philipp Isermann
- Rachel M. Gilbert
Organizations
- Cornell University
- Dutch Research Council
- National Cancer Institute
- National Institutes of Health
- National Science Foundation
- New York Stem Cell Foundation
- Radboud University Medical Centre
- United States Department of Defense
- University of Texas at Austin