Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells
Abstract
Infections, surgeries, and trauma can all cause major tissue damage. Biomaterial scaffolds, which help to guide regenerating tissue, are an exciting emerging therapeutic strategy to promote tissue repair. Sadtler et al. tested how biomaterial scaffolds interact with the immune system in damaged tissue to promote repair (see the Perspective by Badylak). Scaffolds derived from cardiac muscle and bone extracellular matrix components trigger a tissue-reparative T cell immune response in mice with injured muscles.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 15, 2016
- Source ID
- 10.1126/science.aad9272
Entities
People
- Ada J. Tam
- Brandon S. Luber
- Brian W. Allen
- Chirag H. Patel
- Drew M Pardoll
- Franck Housseau
- Hao Wang
- Hongni Fan
- Jennifer Elisseeff
- Jonathan D. Powell
- Kaitlyn Sadtler
- Kathryn R. Wagner
- Kenneth Estrellas
- Matthew T Wolf
Organizations
- Armed Forces Institute of Regenerative Medicine
- Hartwell Foundation
- Johns Hopkins School of Medicine
- Johns Hopkins University
- Maryland Stem Cell Research Fund
- National Institutes of Health
- Research to Prevent Blindness
- United States Department of Defense