Competition between engrams influences fear memory formation and recall
Abstract
Engrams are the changes in brain tissue that store single memories. Neuroscientists can localize and manipulate them, but until now, little was known about how multiple engrams interact to influence memories. Rashid et al. examined how neural assemblies in an area called the lateral amygdala interact. If two frightening events occurred within 6 hours, the same set of neurons was used to express fear memories for both events. However, if the events were separated by 24 hours, distinct memory traces were formed.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 22, 2016
- Source ID
- 10.1126/science.aaf0594
Entities
People
- Antonietta De Cristofaro
- Asim J. Rashid
- Charu Ramakrishnan
- Christina J. Cole
- Hwa-lin (liz) Hsiang
- Julia Yu
- Karl Deisseroth
- Paul W. Frankland
- Sheena A. Josselyn
- Soo Yeun Lee
- Sungmo Park
- Valentina Mercaldo
- Yan Chen
Organizations
- Brain & Behavior Research Foundation
- Brain Canada Foundation
- Canadian Institutes of Health Research
- Defense Advanced Research Projects Agency
- Hospital for Sick Children
- Howard Hughes Medical Institute
- National Institute of Mental Health
- National Institute on Drug Abuse
- Natural Sciences and Engineering Research Council
- Stanford University
- United States Army Research Laboratory
- University of Toronto