On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
Abstract
Commodity chemicals tend to be manufactured in a continuous fashion. However, the preparation of pharmaceuticals still proceeds batch by batch, partly on account of the complexity of their molecular structures. Adamo et al. now present an apparatus roughly the size of a household refrigerator that can synthesize and purify pharmaceuticals under continuous-flow conditions (see the Perspective by Martin). The integrated set of modules can produce hundreds to thousands of accumulated doses in a day, delivered in aqueous solution.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2016
- Source ID
- 10.1126/science.aaf1337
Entities
People
- Allan S Myerson
- Andrea Adamo
- David R. Snead
- Eve M. Revalor
- Jean-christophe M. Monbaliu
- Jie Chen
- Klavs F. Jensen
- Mohsen Behnam
- Nopphon Weeranoppanant
- Ping Zhang
- Rachel L. Beingessner
- Shin Yee Wong
- Timothy F. Jamison
- Torsten Stelzer
Organizations
- Massachusetts Institute of Technology
- Naval Information Warfare Systems Command