Designer nanoscale DNA assemblies programmed from the top down
Abstract
Many intricate nanostructures have been made with DNA origami. This process occurs when a long DNA scaffold develops a particular shape after hybridization with short staple strands. Most designs, however, require a difficult iterative procedure of refining the base pairing. Veneziano et al. now report algorithms that automate the design of arbitrary DNA wireframe structures. Synthesizing and structurally characterizing a variety of nanostructures allowed for verification of the algorithms' accuracy.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 24, 2016
- Source ID
- 10.1126/science.aaf4388
Entities
People
- Fei Zhang
- Hao Yan
- Kaiming Zhang
- Mark Bathe
- Rémi Veneziano
- Sakul Ratanalert
- Wah Chiu
Organizations
- Arizona State University
- Baylor College of Medicine
- Human Frontier Science Program
- Massachusetts Institute of Technology
- National Institutes of Health
- National Science Foundation
- Office of Naval Research