Imprinting and recalling cortical ensembles
Abstract
Donald Hebb's hypothesis that coactivation of neurons leads to the formation of ensembles of neurons has inspired neuroscientists for decades. The experimental creation of such ensembles has been technically challenging. Using two-photon optogenetic stimulation with single-cell resolution, Carrillo-Reid et al. discovered that recurrent activation of a group of neurons creates an ensemble that is imprinted in the brain circuitry. Activation of a single neuron can lead to recall of the entire ensemble in a phenomenon called pattern completion. The artificial ensemble persists over days and can be reactivated at later time points without interfering with endogenous circuitry.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 12, 2016
- Source ID
- 10.1126/science.aaf7560
Entities
People
- Darcy S Peterka
- Luis Carrillo-Reid
- Rafael Yuste
- Weijian Yang
- Yuki Bando
Organizations
- Army Research Office
- Burroughs Wellcome Fund
- Columbia University
- Defense Advanced Research Projects Agency
- National Eye Institute
- National Institute of Mental Health
- Uehara Memorial Foundation
- United States Army Research Laboratory