Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys
Abstract
Zika virus (ZIKV) is responsible for a major ongoing epidemic in the Americas and has been causally associated with fetal microcephaly. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Here we demonstrate that three different vaccine platforms protect against ZIKV challenge in rhesus monkeys. A purified inactivated virus vaccine induced ZIKV-specific neutralizing antibodies and completely protected monkeys against ZIKV strains from both Brazil and Puerto Rico. Purified immunoglobulin from vaccinated monkeys also conferred passive protection in adoptive transfer studies. A plasmid DNA vaccine and a single-shot recombinant rhesus adenovirus serotype 52 vector vaccine, both expressing ZIKV premembrane and envelope, also elicited neutralizing antibodies and completely protected monkeys against ZIKV challenge. These data support the rapid clinical development of ZIKV vaccines for humans.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 09, 2016
- Source ID
- 10.1126/science.aah6157
Entities
People
- Abishek Chandrashekar
- Amanda L. Brinkman
- Arshi Agarwal
- Benjamin C. Lee
- Brad Finneyfrock
- Christine A. Bricault
- Crystal Cabral
- Dan H. Barouch
- David Jetton
- David Ng’ang’a
- Edward T. Moseley
- Erica N. Borducchi
- Galit Alter
- George H. Neubauer
- Jean Pierre S. Peron
- Jessica Jimenez
- Johnathan Misamore
- Katherine Molloy
- Kathryn E. Stephenson
- Kayvon Modjarrad
- Kenneth H Eckels
- Marinela Kirilova
- Mark G. Lewis
- Mayuri Shetty
- Michael Boyd
- Nelson Michael
- Noe B. Mercado
- Ovini Nanayakkara
- Paolo M. De A. Zanotto
- Patricia B. Giglio
- Peter Abbink
- Rafael A. De La Barrera
- Rafael A. Larocca
- Ramya Nityanandam
- Richard G Jarman
- Shanell Mojta
- Stephen J Thomas
- Zhenfeng Li
Organizations
- Harvard Medical School
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- Massachusetts General Hospital
- National Institutes of Health
- São Paulo Research Foundation
- University of São Paulo
- Walter Reed Army Institute of Research