Microtubules acquire resistance from mechanical breakage through intralumenal acetylation
Abstract
Cells need microtubules for intracellular transport and to avoid being crushed. On investigating microtubule breakage in live fibroblasts, Xu et al. found that if they were not acetylated, long-lived microtubules underwent frequent rupture after buckling. Acetylation makes microtubules more mechanically stable, facilitates sliding between filaments, and makes the lattice more plastic.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 21, 2017
- Source ID
- 10.1126/science.aai8764
Entities
People
- Andrea Aguilar
- Didier Portran
- Jérémie Gaillard
- Laura Schaedel
- M. Peter Marinkovich
- Manuel Théry
- Maxence V. Nachury
- Zhenjie Xu
Organizations
- Agence Nationale de la Recherche
- European Research Council
- Human Frontier Science Program
- National Cancer Institute
- National Institute of General Medical Sciences
- Stanford University
- United States Department of Defense