Rapid development of a DNA vaccine for Zika virus
Abstract
The ongoing Zika epidemic in the Americas and the Caribbean urgently needs a protective vaccine. Two DNA vaccines composed of the genes that encode the structural premembrane and envelope proteins of Zika virus have been tested in monkeys. Dowd et al. show that two doses of vaccine given intramuscularly completely protected 17 of 18 animals against Zika virus challenge. A single low dose of vaccine was not protective but did reduce viral loads. Protection correlated with serum antibody neutralizing activity. Phase I clinical trials testing these vaccines are already ongoing.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 14, 2016
- Source ID
- 10.1126/science.aai9137
Entities
People
- Audray Harris
- Barney S. Graham
- Christina R. Demaso
- Dan H. Barouch
- Dana L. Vanlandingham
- David N. Gordon
- Eun Sung Yang
- Hanne Andersen
- John R. Mascola
- John Robert Gallagher
- John-paul Todd
- Kaitlyn M. Morabito
- Kenneth H Eckels
- Kimberly A. Dowd
- Leda R. Castilho
- Mario Roederer
- Mark G. Lewis
- Martha C. Nason
- Michael Boyd
- Peter Abbink
- Rafael De La Barrera
- Ramya Nityanandam
- Rebecca S. Pelc
- Richard G Jarman
- Stephen Higgs
- Sung-Youl Ko
- Theodore C. Pierson
- Wing-pui Kong
- Xuejun Chen
- Yan-Jang S Huang
- Yaroslav Tsybovsky
Organizations
- Federal University of Rio de Janeiro
- Frederick National Laboratory for Cancer Research
- Harvard Medical School
- Kansas State University
- Leidos
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- Walter Reed Army Institute of Research