Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells
Abstract
The stem cell niche is a complex local signaling microenvironment that regulates stem cell activity for tissue and organ maintenance and regeneration. As well as responding locally, during puberty, the mammary gland stem cell niche also responds to systemic hormonal signals. Zhao et al. have found that Gli2, a transcriptional effector of Hedgehog signaling, coordinates the niche-signaling program and activates expression of receptors for the mammatrophic hormones estrogen and growth hormone throughout the mammary gland (see the Perspective by Robertson). Disease may result not only from stem cell defects, but also from dysregulation of the microenvironment.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 21, 2017
- Source ID
- 10.1126/science.aal3485
Entities
People
- Agnes Lim
- Chen Zhao
- Kunyoo Shin
- Michael F Clarke
- Philip A Beachy
- Shang Cai
- Tomer Kalisky
- Wan-Jin Lu
Organizations
- Bar-Ilan University
- Howard Hughes Medical Institute
- Ludwig Institute for Cancer Research
- Pohang University of Science and Technology
- Stanford University
- Susan G. Komen for the Cure
- The Breast Cancer Research Foundation
- United States Department of Defense