Locally translated mTOR controls axonal local translation in nerve injury
Abstract
Localized protein synthesis provides spatiotemporal precision for injury responses and growth decisions at remote positions in nerve axons. Terenzio et al. show that this process is controlled by local translation of preexisting axonal mRNA encoding the master regulator mTOR (see the Perspective by Riccio). mTOR controls both its own synthesis and that of most newly synthesized proteins at axonal injury sites, thereby determining the subsequent survival and growth of the injured neuron.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 23, 2018
- Source ID
- 10.1126/science.aan1053
Entities
People
- Agostina Di Pizio
- Alma L. Burlingame
- Anatoly Urisman
- Ashley Kalinski
- Craig M Forester
- Cynthia Gomes
- Ella Doron-Mandel
- Ida Rishal
- Indrek Koppel
- Jeffery L Twiss
- Juan A Oses-Prieto
- Letizia Marvaldi
- Marco Terenzio
- Mike Fainzilber
- Nitzan Samra
- Pabitra K Sahoo
- Qian Zhao
- Rotem Ben-tov Perry
- Sandip Koley
Organizations
- Adelson Foundation
- Congressionally Directed Medical Research Programs
- Drexel University
- European Research Council
- Israel Science Foundation
- Minerva Stiftung
- National Institutes of Health
- University of California
- University of South Carolina
- Weizmann Institute of Science