Reconfiguration of DNA molecular arrays driven by information relay
Abstract
Arrays of modular DNA units can relay information by transforming their internal shape in response to binding of DNA trigger strands. Song et al. synthesized rectangular arrays of double-stranded DNA (see the Perspective by Yang and Lin). Transient square configurations transform into two stable rectangular structures by pinching across a pair of opposing vertices. Binding of DNA trigger strands causes switching into the alternative stable configuration. The tiles thus create a cascade of transformations along a particular pathway, thereby transmitting information about where binding occurred.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 28, 2017
- Source ID
- 10.1126/science.aan3377
Entities
People
- Chengde Mao
- Jie Song
- Pengfei Wang
- Travis Meyer
- Yonggang Ke
- Zhe Li
Organizations
- Emory University
- National Natural Science Foundation of China
- National Science Foundation
- Office of Naval Research
- Purdue University
- Shanghai Jiao Tong University