Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche
Abstract
Macrophages engulf damaged and dead cells to clear infection, but they also participate in tissue regeneration. Chakrabarti et al. expand the macrophage repertoire for mammary gland development (see the Perspective by Kannan and Eaves). Mammary gland stem cells secrete the Notch ligand Dll1 and activate Notch signaling, which promotes survival of adjacent macrophages. This stimulates production of Wnt ligands, which signal back to the mammary gland stem cells. This cross-talk plays an important role in coordinating mammary gland development, tissue homeostasis, and, not least, breast cancer.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 29, 2018
- Source ID
- 10.1126/science.aan4153
Entities
People
- Abrar Choudhury
- Briana G. Nixon
- Christina DeCoste
- Hans Clevers
- Iannis Aifantis
- Jie Gao
- Johan H. Van Es
- John J Grady
- Julie Hwang
- Ming O Li
- Peng Jia
- Rumela Chakrabarti
- Sushil Kumar
- Toni Celià-Terrassa
- Xiang Hang
- Yibin Kang
- Yong Wei
Organizations
- Memorial Sloan Kettering Cancer Center
- National Cancer Institute
- National Institutes of Health
- New York University
- Princeton University
- Royal Netherlands Academy of Arts and Sciences
- Rutgers University–New Brunswick
- United States Department of Defense
- University of Pennsylvania