Diurnal transcriptome atlas of a primate across major neural and peripheral tissues
Abstract
Much of our knowledge about the important effects of circadian rhythms in physiology comes from studies of mice, which are nocturnal. Mure et al. report transcriptional profiles from many tissues and brain regions in baboons over a 24-hour period (see the Perspective by Millius and Ueda). The results emphasize how extensive rhythmic expression is, with more than 80% of protein-coding genes involved. They also highlight unanticipated differences between the mouse and baboon in the cycling of transcripts in various tissues. The findings provide a comprehensive analysis of circadian variation in gene expression for a diurnal animal closely related to humans.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 16, 2018
- Source ID
- 10.1126/science.aao0318
Entities
People
- Giorgia Benegiamo
- Hiep D Le
- Howard M Cooper
- Luis Rios
- Maina Ngotho
- Max W Chang
- Ngalla Jillani
- Ouria Dkhissi-Benyahya
- Satchidananda Panda
- Thomas Kariuki
- ludovic mure
Organizations
- Institute of Primate Research
- Salk Institute for Biological Studies
- United States Department of Defense
- University of California, San Diego