Single-stranded DNA and RNA origami
Abstract
Nanostructures created by origami-like folding of nucleic acids are usually formed by base-pairing interactions between multiple strands. Han et al. show that large origami (up to 10,000 nucleotides for DNA and 6000 nucleotides for RNA) can be created in simple shapes, such as a rhombus or a heart. A single strand can be folded smoothly into structurally complex but knot-free structures by using partially complemented double-stranded DNA and the cohesion of parallel crossovers. The use of single strands also enables in vitro synthesis of these structures.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 15, 2017
- Source ID
- 10.1126/science.aao2648
Entities
People
- Bei Wang
- Byoungkwon An
- Cameron Myhrvold
- Dongran Han
- Fei Zhang
- Hao Yan
- Maxwell Bates
- Mingjie Dai
- Peng Yin
- Shuoxing Jiang
- Xiaodong Qi
- Yan Liu
Organizations
- Arizona State University
- Army Research Office
- Biodesign Institute
- China Scholarship Council
- Harvard Medical School
- Harvard University
- National Science Foundation
- Office of Naval Research
- University of Science and Technology of China
- autodesk.com