Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice
Abstract
Cancer patients who have undergone successful treatment can experience relapse of their disease years or even decades later. This is because cancer cells that have disseminated beyond the primary tumor site enter a state of dormancy, where they remain viable but not proliferating. Eventually, by mechanisms that are poorly understood, these clinically undetectable cells “wake up” and form actively growing metastases. Studying mouse models, Albrengues et al. found that sustained lung inflammation and the accompanying formation of neutrophil extracellular traps (NETs) could convert dormant cancer cells to aggressive lung metastases (see the Perspective by Aguirre-Ghiso). Awakening of these cells was associated with NET-mediated remodeling of the extracellular matrix and could be prevented by an antibody against the remodeled version of a matrix protein called laminin-111.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 28, 2018
- Source ID
- 10.1126/science.aao4227
Entities
People
- Alexandra Ambrico
- Arnaud Pommier
- Carmelita Bautista
- Chun Gwon Park
- Dale L Uyeminami
- David Ng
- Douglas T Fearon
- Ellese M. Carmona
- Emilis Bružas
- Jean Albrengues
- Johannes T-H Yeh
- Kenneth Chang
- Kent E Pinkerton
- Laura Maiorino
- Lloyd Trotman
- Mario A Shields
- Michael S Goldberg
- Mikala Egeblad
- Morgan E Poindexter
- Phyllis A. Gimotty
- Priya Upadhyay
- Scott K Lyons
- Victoria Küttner
Organizations
- Association pour le développement de la recherche sur le cancer
- Boehringer Ingelheim Fonds
- Cold Spring Harbor Laboratory
- Dana–Farber Cancer Institute
- European Molecular Biology Organization
- German Research Foundation
- Harvard Medical School
- Lustgarten Foundation for Pancreatic Cancer Research
- National Cancer Institute
- Northwell Health
- Susan G. Komen for the Cure
- United States Department of Defense
- University of California
- University of Cambridge
- University of Pennsylvania
- Watson School of Biological Sciences
- Weill Cornell Medicine