Chemically induced proximity in biology and medicine
Abstract
The physical distance, or proximity, between molecules often directs biological events. The development of membrane-permeable small molecules that reversibly regulate proximity has enabled advances in fields such as synthetic biology, signal transduction, transcription, protein degradation, epigenetic memory, and chromatin dynamics. This “induced proximity” can also be applied to the development of new therapeutics. Stanton et al. review the wide range of advances and speculate on future applications of this fundamental approach.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 09, 2018
- Source ID
- 10.1126/science.aao5902
Entities
People
- Benjamin Z Stanton
- Emma Chory
- Gerald Crabtree
Organizations
- Howard Hughes Medical Institute
- National Cancer Institute
- National Institutes of Health
- National Science Foundation Office of the Director
- Simons Foundation
- Stanford University
- United States Department of Energy