VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma
Abstract
Many clear cell renal cell carcinomas (ccRCCs) have alterations to the gene encoding the von Hippel-Lindau protein (VHL). VHL is a ubiquitin ligase that degrades target proteins when they are prolyl-hydroxylated. Zhang et al. performed a genome-wide search for VHL target (see the Perspective by Sanchez and Simon). They identified ZHX2, a protein with structural motifs that indicate DNA binding. ZHX2 has been implicated in tumor suppression. Loss of ZHX2 inhibited signaling through the transcription factor NF-κB, and ZHX2 bound to many NF-κB target genes. Depletion of ZHX2 slowed growth of ccRCC cells in vitro and in a mouse model.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 20, 2018
- Source ID
- 10.1126/science.aap8411
Entities
People
- Albert S Baldwin
- Bin Tean Teh
- Charles M. Perou
- Chengheng Liao
- Cortney Lawrence
- Eric Jonasch
- Giada Zurlo
- Huihui Fan
- James Auman
- Jeremy M Simon
- Jiang Geng
- Jie Fan
- Jing Zhang
- Joel S Parker
- Jun Wang
- Kai Hong
- Lianxin Hu
- Ling Xie
- Mamoru Takada
- Marc Kirschner
- Mingjie Li
- Patrick Tan
- Qing Zhang
- Ryoichi Saito
- Tao Wu
- W. Kimryn Rathmell
- William G. Kaelin
- William Y. Kim
- Xian Chen
- Xian-De Liu
- Xiaosai Yao
- Xijuan Liu
- Xingnan Zheng
Organizations
- Agency for Science, Technology and Research
- Duke–NUS Medical School
- Fudan University
- Harvard Medical School
- Istituto Superiore di Sanità
- Korea National Institute of Health
- National Cancer Institute
- Tongji University
- United States Department of Defense
- University of North Carolina
- University of Texas at Austin
- Vanderbilt University