NUFIP1 is a ribosome receptor for starvation-induced ribophagy
Abstract
Autophagosomes engulf and degrade cellular components in lysosomes. Degradation of ribosomes is called ribophagy and is an important source of nutrients. Using a recently reported method to isolate lysosomes, Wyant et al. profiled the dynamics of the lysosomal proteome under different nutrient conditions (see the Perspective by Nofal and Rabinowitz). The protein NUFIP1 is an autophagy receptor for ribosomes during starvation-induced ribophagy. NUFIP1 shuttles out of the nucleus and targets its ribosome cargo directly by binding to an autophagosome protein. Loss of NUFIP1 means failure to provide sufficient nucleotides during starvation and, therefore, loss of cells under low nutrient conditions.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 18, 2018
- Source ID
- 10.1126/science.aar2663
Entities
People
- Alessandro Ori
- Caroline A Lewis
- David M. Sabatini
- Evgeni M. Frenkel
- Gregory A Wyant
- Ivonne Heinze
- Monther Abu-Remaileh
- Nouf N Laqtom
- Sze Ham Chan
- Vimisha Dharamdasani
Organizations
- Broad Institute
- Fritz Lipmann Institute
- Glenn Foundation for Medical Research
- Massachusetts Institute of Technology
- Office of the Director
- United States Department of Defense