Detection and localization of surgically resectable cancers with a multi-analyte blood test
Abstract
Many cancers can be cured by surgery and/or systemic therapies when detected before they have metastasized. This clinical reality, coupled with the growing appreciation that cancer's rapid genetic evolution limits its response to drugs, have fueled interest in methodologies for earlier detection of the disease. Cohen et al. developed a noninvasive blood test, called CancerSEEK that can detect eight common human cancer types (see the Perspective by Kalinich and Haber). The test assesses eight circulating protein biomarkers and tumor-specific mutations in circulating DNA. In a study of 1000 patients previously diagnosed with cancer and 850 healthy control individuals, CancerSEEK detected cancer with a sensitivity of 69 to 98% (depending on cancer type) and 99% specificity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 23, 2018
- Source ID
- 10.1126/science.aar3247
Entities
People
- Aaron Mansfield
- Alison P Klein
- Ammar A Javed
- Anne Marie Lennon
- Austin Mattox
- Bahman Afsari
- Bert Vogelstein
- Chetan Bettegowda
- Christopher Douville
- Christopher L Wolfgang
- Christopher Thoburn
- Cristian Tomasetti
- Fay Wong
- Hui-li Wong
- James D. Browne
- Janine Ptak
- Jeanne Tie
- Jin Jen
- Joshua David Cohen
- Joshua T Vogelstein
- Joy Schaefer
- Kenneth W. Kinzler
- Lisa Dobbyn
- Lu Li
- Ludmila Danilova
- Luis Alberto Diaz Jr
- Marco Dal Molin
- Maria Popoli
- Massimo Falconi
- Michael Goggins
- Natalie Silliman
- Nickolas Papadopoulos
- Peter Gibbs
- Peter J. Allen
- Ralph H. Hruban
- Randall E Brand
- Richard B S Roden
- Robert E Schoen
- Samir M Hanash
- Shibin Zhou
- Tian-li Wang
- Yuxuan Wang
Organizations
- Billi and Bernie Marcus Foundation
- Commonwealth Fund
- Doris Duke Charitable Foundation
- John Templeton Foundation
- Johns Hopkins School of Medicine
- Johns Hopkins University
- Ludwig Institute for Cancer Research
- Lustgarten Foundation for Pancreatic Cancer Research
- Mayo Clinic
- Memorial Sloan Kettering Cancer Center
- National Institutes of Health
- Peter MacCallum Cancer Centre
- University of Melbourne
- University of Pittsburgh
- University of Texas at Austin
- WEHI
- Western Health