Hachimoji DNA and RNA: A genetic system with eight building blocks
Abstract
DNA and RNA are naturally composed of four nucleotide bases that form hydrogen bonds in order to pair. Hoshika et al. added an additional four synthetic nucleotides to produce an eight-letter genetic code and generate so-called hachimoji DNA. Coupled with an engineered T7 RNA polymerase, this expanded DNA alphabet could be transcribed into RNA. Thus, new forms of DNA that add information density to genetic biopolymers can be generated that may be useful for future synthetic biological applications.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 22, 2019
- Source ID
- 10.1126/science.aat0971
Entities
People
- Adam J Meyer
- Alison Bates
- Andrew D Ellington
- Holly A SantaLucia
- Hyo-Joong Kim
- John SantaLucia
- Joseph A Piccirilli
- Millie M. Georgiadis
- Myong-Jung Kim
- Myong-Sang Kim
- Nicole A Leal
- Nilesh B Karalkar
- Norman E Watkins
- Saurja DasGupta
- Shuichi Hoshika
- Steven A. Benner
Organizations
- Defense Threat Reduction Agency
- Foundation for Applied Molecular Evolution
- Indiana University School of Medicine
- John Templeton Foundation
- National Aeronautics and Space Administration
- National Institutes of Health
- Templeton World Charity Foundation
- United States Department of Energy
- University of Chicago
- University of Texas at Austin