Minimal functional driver gene heterogeneity among untreated metastases
Abstract
Treatment decisions for cancer patients are increasingly guided by analysis of the gene mutations that drive primary tumor growth. Relatively little is known about driver gene mutations in metastases, which cause most cancer-related deaths. Reiter et al. explored whether the growth of different metastatic lesions within an individual patient is fueled by the same or distinct gene mutations. In a study of 76 untreated metastases from 20 patients with different types of cancer, all metastases within a patient shared the same functional driver gene mutations. Thus, analysis of a single biopsy could help oncologists select the optimal therapy for patients with widespread metastatic disease.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 07, 2018
- Source ID
- 10.1126/science.aat7171
Entities
People
- Alexander Heyde
- Alexia Brown
- Alvin P. Makohon-moore
- Amanda Zucker
- Bert Vogelstein
- Christine A Iacobuzio-Donahue
- Collin J Tokheim
- Jeffrey M Gerold
- Johannes G Reiter
- Juliana Niyazov
- Kenneth W. Kinzler
- Marc A Attiyeh
- Martin A. Nowak
- Rachel Karchin
- Rayne M DeBlasio
- Zachary A Kohutek
Organizations
- Austrian Science Fund
- Harvard University
- Howard Hughes Medical Institute
- Johns Hopkins University
- Ludwig Institute for Cancer Research
- Lustgarten Foundation for Pancreatic Cancer Research
- Memorial Sloan Kettering Cancer Center
- National Institutes of Health
- Office of Naval Research
- Sidney Kimmel Comprehensive Cancer Center
- Stanford University