SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism
Abstract
One-carbon (1C) metabolism is a universal metabolic process that is required for purine synthesis and supports the high levels of proliferation in cancer cells. The transport of serine into mitochondria supplies most of the 1C units needed for biosynthesis. Kory et al. used a genetic screen to identify the long-sought-after mitochondrial serine transporter. Elucidating the key step of serine transport is important for our understanding of metabolism and has potential implications for cancer treatment.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 16, 2018
- Source ID
- 10.1126/science.aat9528
Entities
People
- Caroline A Lewis
- David M. Sabatini
- Francesca Bottanelli
- Gregory A Wyant
- Gyan Prakash
- Heather R Keys
- Jelmi Uit de Bos
- Michael E Pacold
- Nora Kory
- Sze Ham Chan
- Tim Wang
- Yang Eric Guo
Organizations
- Damon Runyon Cancer Research Foundation
- Howard Hughes Medical Institute
- Massachusetts Institute of Technology
- National Institutes of Health
- New York University
- United States Department of Defense
- Whitehead Institute
- Yale University