Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway
Abstract
The protein PTEN is a phosphatase and tumor suppressor whose activity is often decreased in human cancers. Thus, reactivating such a protein could potentially be an effective therapy against cancer. Lee et al. identified a ubiquitin E3 ligase (WWP1) as a PTEN-interacting protein that modifies PTEN and inhibits its tumor suppressive activity (see the Perspective by Parsons). Depletion of WWP1 increased dimerization and membrane recruitment of PTEN. A natural compound found to be a pharmacological inhibitor of WWP1 inhibited tumor growth in a mouse model of prostate cancer. Thus, reactivation of the tumor suppressor PTEN may provide a strategy for battling tumors.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 17, 2019
- Source ID
- 10.1126/science.aau0159
Entities
People
- Antonella Papa
- Assaf C. Bester
- Chen Shen
- Chih-Hung Hsu
- Emanuele Monteleone
- Hao Chen
- Hao Wu
- Jacqueline Fung
- Jesse Katon
- Jinfang Zhang
- John G Clohessy
- Jonathan D. Lee
- Julie Teruya-feldstein
- Lixin Wan
- Lydia Matesic
- Ming Chen
- Pier Paolo Pandolfi
- Ruey-hwa Chen
- Shang-yin Chiang
- Shu-yu Lin
- Suresh Jain
- Tian-Min Fu
- Tomoki Ishikawa
- Wenyi Wei
- Yang Zhang
- Yu-Ru Lee
- Yulia V Shulga
Organizations
- Academia Sinica
- Boston Children's Hospital
- H. Lee Moffitt Cancer Center & Research Institute
- Harvard Medical School
- Icahn School of Medicine at Mount Sinai
- Monash University
- Office of the Director
- United States Department of Defense
- University of South Carolina
- University of Turin
- Zhejiang University School of Medicine