Cerebrospinal fluid influx drives acute ischemic tissue swelling
Abstract
The brain is enveloped in a cushion of cerebrospinal fluid (CSF), which normally provides protection and helps to remove metabolic waste. CSF transport has also recently been shown to play unexpected roles in neurodegeneration and sleep. Mestre et al. used multimodal in vivo imaging in rodents and found that, after a stroke, an abnormally large volume of CSF rushes into the brain, causing swelling (see the Perspective by Moss and Williams). This influx of CSF is caused by constrictions of arteries triggered by a well-known propagating chemical reaction-diffusion wave called spreading depolarization. CSF transport can thus play a role in brain swelling after stroke.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 13, 2020
- Source ID
- 10.1126/science.aax7171
Entities
People
- Amanda M. Sweeney
- Andrew J Samson
- David Kleinfeld
- Douglas H Kelley
- Edna R. Toro
- Erik A. Martens
- Frederik Filip Stæger
- Guojun Liu
- Hajime Hirase
- Humberto Mestre
- Jeffrey Tithof
- John H Thomas
- Kristian N Mortensen
- Logan Bashford
- Maiken Nedergaard
- Orestes Solis
- Pablo Blinder
- Peter A R Bork
- Poul G. Hjorth
- Rupal I. Mehta
- Ting Du
- Weiguo Peng
- Yuki Mori
Organizations
- Army Research Office
- Horizon 2020
- Leducq Foundation
- Lundbeck Foundation
- National Institute of Neurological Disorders and Stroke
- National Institute on Aging
- Novo Nordisk Fonden
- Rush University
- Tel Aviv University
- University of California, San Diego
- University of Copenhagen
- University of Rochester