Designed protein logic to target cells with precise combinations of surface antigens
Abstract
A major challenge in medical interventions is to target only diseased cells. Although there are biomarkers characteristic of certain cancers, for example, it is unlikely that a single marker can specify a particular cell type. Lajoie et al. addressed this problem by designing protein switches called Co-LOCKR that bind to antigens on the cell surface and activate through a conformational change only when there is a precise combination of antigens. They designed switches that can perform AND, OR, and NOT logic. On the path toward applying this technology, they used Co-LOCKR to direct chimeric antigen receptor T cells to tumor cells expressing specific antigens.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 25, 2020
- Source ID
- 10.1126/science.aba6527
Entities
People
- Alexander Salter
- Alfredo Quijano-Rubio
- Alisha Nguyen
- Anusha Rajan
- Audrey Olshefsky
- Colin E Correnti
- David Baker
- Garreck H Lenz
- Jaylee Johnson
- Jilliane Bruffey
- Marc J. Lajoie
- Matthew J Bick
- Mesfin M Gewe
- Robert A. Langan
- Scott E Boyken
- Stanley R Riddell
- Suzie H. Pun
- Vishaka Muhunthan
Organizations
- Burroughs Wellcome Fund
- Cancer Research Institute
- Defense Threat Reduction Agency
- Fred Hutchinson Cancer Center
- Hearst Foundations
- Howard Hughes Medical Institute
- National Cancer Institute
- National Institute of General Medical Sciences
- National Institutes of Health
- National Science Foundation
- Open Philanthropy Project
- University of Washington
- Washington Research Foundation