A universal system for digitization and automatic execution of the chemical synthesis literature
Abstract
A typical chemist running a known reaction will start by finding the method described in a published paper. Mehr et al. report a software platform that uses natural language processing to translate the organic chemistry literature directly into editable code, which in turn can be compiled to drive automated synthesis of the compound in the laboratory. The synthesis procedure is intended to be universally applicable to robotic systems operating in a batch reaction architecture. The full process is demonstrated for synthesis of an analgesic as well as common oxidizing and fluorinating agents.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 02, 2020
- Source ID
- 10.1126/science.abc2986
Entities
People
- Artem I Leonov
- Graham Keenan
- Leroy Cronin
- Matthew Craven
- S Hessam M Mehr
Organizations
- Engineering and Physical Sciences Research Council
- University of Glasgow