Broad neutralization of SARS-related viruses by human monoclonal antibodies
Abstract
As scientists develop therapeutic antibodies and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the risk of emergent coronaviruses makes it important to also identify broadly protective antibodies. Wec et al. isolated and characterized hundreds of antibodies against the viral spike protein of SARS-CoV-2 from the memory B cells of a survivor of the 2003 outbreak caused by the related coronavirus, SARS-CoV. In both of these viruses, the spike protein facilitated viral entry by binding to the angiotensin-converting enzyme 2 (ACE2) receptor on human cells. The antibodies targeted multiple sites on the spike protein, but of nine antibodies that showed strong cross-neutralization, eight targeted the domain that binds to ACE2. These eight antibodies also neutralized a bat SARS-related virus. Illuminating the epitopes on the viral spike protein that bind cross-neutralizing antibodies could guide the design of broadly protective vaccines.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 07, 2020
- Source ID
- 10.1126/science.abc7424
Entities
People
- Andrew S Herbert
- Anna Z Wec
- Ariel S Wirchnianski
- Asparouh Lilov
- Barney S. Graham
- Carl H. Johnson
- Catalina Florez
- Cecilia M O'Brien
- Ching-Lin Hsieh
- Daniel P. Maurer
- Daniel Wrapp
- David Nemazee
- Deli Huang
- Denise Haslwanter
- Dennis R. Burton
- Elizabeth Champney
- Ethan Laudermilch
- Irina Burnina
- James E Voss
- Jason S. McLellan
- Jens Maximilian Fels
- John M Dye
- Juergen H Nett
- Kartik Chandran
- Laura M Walker
- Longping V Tse
- María Dieterle
- Melanie Sinclair
- Michael E. Brown
- Mrunal Sakharkar
- Nianshuang Wang
- Nicole V Johnson
- Ralph S. Baric
- Robert H. Bortz
- Rohit K Jangra
- Sarat Pudi
- Shu Lin
Organizations
- Albert Einstein College of Medicine
- Massachusetts Institute of Technology
- National Institutes of Health
- Scripps Research
- United States Army Medical Research Institute of Infectious Diseases
- University of North Carolina at Chapel Hill
- University of Texas at Austin