Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Abstract
The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals that lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody system dampens IFN response to prevent damage from pathogen-induced inflammation. Two studies now examine the likelihood that genetics affects the risk of severe coronavirus disease 2019 (COVID-19) through components of this system (see the Perspective by Beck and Aksentijevich). Q. Zhang et al. used a candidate gene approach and identified patients with severe COVID-19 who have mutations in genes involved in the regulation of type I and III IFN immunity. They found enrichment of these genes in patients and conclude that genetics may determine the clinical course of the infection. Bastard et al. identified individuals with high titers of neutralizing autoantibodies against type I IFN-α2 and IFN-ω in about 10% of patients with severe COVID-19 pneumonia. These autoantibodies were not found either in infected people who were asymptomatic or had milder phenotype or in healthy individuals. Together, these studies identify a means by which individuals at highest risk of life-threatening COVID-19 can be identified.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 23, 2020
- Source ID
- 10.1126/science.abd4570
Entities
People
- A. H. (koos) Zwinderman
- Abián Montesdeoca Melián
- Adam Klocperk
- Adeline Blandinières
- Adem Karbuz
- Adolfo García-Sastre
- Adrián Muñoz-barrera
- Agatha Schluter
- Agnes Linglart
- Agurtzane Bilbao
- Agustí Rodríguez-palmero
- Ahmed A. Bousfiha
- Aileen Camille Ugurbil
- Alberto Pesci
- Alejandro D. Iglesias
- Alessandra Renieri
- Alessandra Sottini
- Alessandra Tucci
- Alessandro Aiuti
- Alessia David
- Alex Cloherty
- Alex Schuurman
- Alex Serra Ilovich
- Alexander P.j. Vlaar
- Alexandra Beurton
- Alexandra Coelho
- Alexandre Belot
- Alexandre Bolze
- Alexandre Demoule
- Alexandre Gaymard
- Alexandre Hoctin
- Alexis Mathian
- Ali Amara
- Ali Sobh
- Aline Dechanet
- Alper Yosunkaya
- Alpha Diallo
- Alphonsine Diouf
- Amin Dehban
- Amina Meziane
- Amsterdam Umc Covid-19 Biobank
- Ana Maria Van Den Rym
- Anastasiia Bondarenko
- Andrea Biondi
- Andrea E Martin
- Andrea Martin-Nalda
- Andreea Postolache
- Andres A Arias
- Andres Augusto Arias
- Andrew J Oler
- Andrew L. Snow
- András N. Spaan
- András Spaan
- Anissa Chair
- Anissa Tsonas
- Anna Codina
- Anna Geke Algera
- Anna M Planas
- Anna Sediva
- Annabelle Stoclin
- Anna‐Lena Neehus
- Anne Leclercq
- Anne Puel
- Anne-sophie Rebillat
- Antoine Guerder
- Antoine Khalil
- Antonin Falck
- Antonio Condino-neto
- Antonio Morales Martinez
- Antonio Novelli
- Antonio Íñigo-campos
- Anya Rothenbuhler
- Armand Girbes
- Arnau Antolí
- Audrey Vincent
- Aurora Pujol
- Aurore Pouliet
- Aurélie Baldolli
- Aurélie Cobat
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Aurélien Corneau
- Aurélien Philippe
- Axelle Azot
- Barnaby E. Young
- Bart Geerts
- Bart Loeys
- Bart N. Lambrecht
- Benedetta Bigio
- Benedikt Preckel
- Benjamin Terrier
- Benoit Barrou
- Benoit Visseaux
- Bertrand Boisson
- Beth A. Drolet
- Blanca Amador-borrero
- Blanca Garcia Solis
- Bonaventura Clotet
- Bradly M. Bauman
- Bram Goorhuis
- Brandon S Razooky
- Bruno Charbit
- Bruno Coignard
- Bruno Francois
- Bruno Lina
- Bénédicte Rossignol
- Camille Alba
- Camille Couffignal
- Camillo Rossi
- Carine Roy
- Carlos Casasnovas
- Carlos D. Bustamante
- Carlos Flores
- Carlos Rodrigo
- Carlos Rodríguez-Gallego
- Carolina Prando
- Carolina Soledad Romero
- Caroline Quintin
- Caroline Semaille
- Caroline Thumerelle
- Carrie L. Lucas
- Catherine Lubetzki
- Catherine Soler
- Cathérine Heijmans
- Cecilia B. Korol
- Charlene Da Silveira
- Charles Burdet
- Charles M. Rice
- Charles-edouard Luyt
- Charlotte Charpentier
- Charlotte Teunissen
- Cheng-lung Ku
- Christelle Delmas
- Christelle Paul
- Christelle Tual
- Christine Bole-feysot
- Christophe Parizot
- Christopher R. Luthers
- Claire Andrejak
- Claire Bouvattier
- Claire Levy-marchal
- Clifton L Dalgard
- Cliona O’farrelly
- Clotilde Mircher
- Cloé Comarmond
- Clémence Mordacq
- Coralie Khan
- Coralie Tardivon
- Cornelis S. Stijnis
- Cov-contact Cohort
- Covid Clinicians
- Covid Human Genetic Effort
- Covid-storm Clinicians
- Cyril E. Schweitzer
- Cyril Nafati
- Cécile Masson
- Cédric Bosteels
- Cédric Laouenan
- Cédric Vilain
- Céline Dorival
- Céline Louapre
- Damien Sene
- Daniel Blazquez-gamero
- Daniel Leung
- Daniel M. Hupalo
- Darragh Duffy
- David C. Lye
- David Dalmau
- David Hagin
- David Lebeaux
- David M. Smadja
- David Martínez Pueyo
- David Ross Darley
- Davood Mansouri
- Davoud Mansouri
- Dehbia Benkerrou
- Delphine Bachelet
- Denis Malvy
- Denise Veelo
- Diane Bax
- Diane Descamps
- Didier Raoult
- Diederik van de Beek
- Dominique Deplanque
- Dominique Ploin
- Donald C Vinh
- Dorien Wouters
- Dusan Bogunovic
- Edgar Peters
- Elana Shaw
- Eleftherios Michailidis
- Elena Hsieh
- Elisa Hernandez-brito
- Elizabeth Cirulli
- Emila Ilic-habensus
- Emilie Catherinot
- Emine Hafize Erdeniz
- Emmanuelle Jouanguy
- Eric Caumes
- Eric D’ortenzio
- Eric Hoste
- Eric Karlins
- Ernesto Contro
- Esmeralda Nuñez Cuadros
- Estela Paz-artal
- Esther Bulle
- Eugenia Quiros-roldan
- Eva Van Braeckel
- Fabio Taccone
- Fahad Alsohime
- Fahd Al-mulla
- Faiez Zannad
- Fanny Bajolle
- Fanny Onodi
- Fanny Vuotto
- Fatih Colkesen
- Fatih Yucel
- Fatma Çölkesen
- Feras Almourfi
- Fikret Kanat
- Filomeen Haerynck
- Fleur Le Bourgeois
- Flore Rozenberg
- Florence Damond
- Florentia Kaguelidou
- Florian Krammer
- Florianne Hafkamp
- France Mentré
- Francesca Fusco
- Francesco Castelli
- Francesco Scolari
- Franck Rapaport
- Frank Van Baarle
- François Angoulvant
- François Bompart
- François Dubos
- François Téoulé
- François-xavier Lescure
- Frederic Tores
- Frederique Paulus
- French Covid Cohort Study Group
- Funda Gok
- Furkan Uddin
- Gabriele Tomasoni
- Gail V. Matthews
- Gaspard Kerner
- Gauthaman Sukumar
- Gemma Rocamora Blanch
- Geoffroy Delplancq
- Geraldine Blanchard-rohner
- Giacomo Bellani
- Gilles Peytavin
- Giorgio Casari
- Giovanna Fabio
- Giuseppe Citerio
- Giuseppe Foti
- Giuseppe Novelli
- Godelieve De Bree
- Guillaume Lingas
- Guillaume Morelle
- Guillaume Smits
- Guillaume Voiriot
- Gulsum Alkan
- Guy Gorochov
- Géraldine Poncelet
- Hagit Baris Feldman
- Hans Slabbynck
- Hans-Heinrich Hoffmann
- Harm Jan Bogaard
- Hasan Kapakli
- Haya Al-saud
- Heder De Vries
- Helen Su
- Hervé Le Nagard
- Horst Von Bernuth
- Hugo Mouquet
- Huie Jing
- Hulya Vatansev
- Hélène Espérou
- Iciar Marzana
- Ignacio Blanco
- Ilad Alavi Darazam
- Imagine Covid Group
- Iolanda Jordan
- Ira K. D. Sabli
- Isabelle Gorenne
- Isabelle Hoffmann
- Isabelle Melki
- Isabelle Meyts
- Isabelle Migeotte
- Isabelle Vandernoot
- Iskender Kara
- Ismail Reisli
- J. Gonzalo Ocejo-vinyals
- Jacinta Bustamante
- Jacques Fellay
- Jacques G Rivière
- Jade Ghosn
- Jade Rexach
- Jan M. Prins
- Janneke Horn
- Javier Martinez-Picado
- Jean Christophe Lucet
- Jean-Laurent Casanova
- Jean-christophe Goffard
- Jean-christophe Lagier
- Jean-christophe Lucet
- Jean-christophe Richard
- Jean-françois Meritet
- Jean-françois Timsit
- Jean-louis Mège
- Jean-luc Diehl
- Jean-luc Ecobichon
- Jean-luc Taupin
- Jeaninne Nellen
- Jens Van Praet
- Jeremie Guedj
- Jerome Allardet-servent
- Jesus Marquez Pereira
- Jesus Troya
- Ji Eun Han
- Jie Chen
- Jim Heath
- Jimmy Mullaert
- Joan Sabater Riera
- John Christodoulou
- John Kikoine
- John Rosenberger
- Jonathan Lehacaut
- Joppe W. Hovius
- Jordi Solé-violán
- Jorg Hamann
- Jorge Abad
- Jorinde Raasveld
- Jose Luis Franco
- Josep Trenado Alvarez
- Joseph L. Derisi
- Joshua D. Milner
- Joshua Milner
- José M. Lorenzo-salazar
- João Farela Neves
- Juan C. Aldave
- Juan José Cáceres Agra
- Juan Li
- Juan Pablo Horcajada
- Juan Valencia-ramos
- Juana Gil-herrera
- Julia Bielicki
- Julie Toubiana
- Julien Mayaux
- Julien Poissy
- Junqiang Ye
- Justin De Brabander
- Justin Lack
- Justina Motiejunaite
- Justine Pages
- Jérémie Le Pen
- Jérémie Rosain
- Jérémy Manry
- Jérôme Hadjadj
- Kadriye Kart Yasar
- Kadriye Yaşar
- Kai Kisand
- Karim Dorgham
- Karine K. A. Amat
- Kaya Bilguvar
- Kazuyuki Meguro
- Kelly Schiabor Barrett
- Kim Sigaloff
- Kohsuke Imai
- Krishna Bhavsar
- Kristina Mironska
- Laia Alsina
- Larissa R. B. Matos
- Laszlo Marodi
- Laura Hagens
- Laura Planas-serra
- Laura Rachele Bettini
- Laurence Faivre
- Laurent Abel
- Laurent Gilardin
- Laurent Renia
- Layidé Roufai
- Lazaro Lorenzo
- Leen Moens
- Lennart Hammarström
- Leo Heunks
- Leslie Naesens
- Levi Hoste
- Lieuwe Bos
- Lila Bouadma
- Linda Humbert
- Lisa F. P. Ng
- Lixin Zheng
- Lluís Quintana-Murci
- Loic De Pontual
- Loubna Alavoine
- Lucas Fleuren
- Lucie Bonnet-Madin
- Lucie Roussel
- Lucy Bizien
- Luigi D Notarangelo
- Luis M Allende
- Luis M. Seijo
- Luisa Imberti
- Lysa Tagherset
- Léa Karpf
- Maite Ballester
- Majid Marjani
- Manish J. Butte
- Manuel Etienne
- Manuel Rosa-calatrava
- Marc Van Der Valk
- Marcela Moncada‐Vélez
- Marcus J. Schultz
- Maria Carrabba
- Maria Grazia Valsecchi
- Maria Rita P. Bueno
- Maria Yolanda Ruiz Del Prado
- Mariama Nouroudine
- Marianna Bugiani
- Marie E. Vilaire
- Marie Pouletty
- Marie-alexandra Alyanakian
- Marie-capucine Tellier
- Marie-pierre Debray
- Mariella D’angio’
- Marije Bomers
- Marina Cazzaniga
- Marina Esposito-farese
- Marina Mambert
- Marine Beluze
- Marion Caseris
- Marion Noret
- Marion Schneider
- Mark S. Anderson
- Marketa Bloomfield
- Markus W. Hollmann
- Marry Smit
- Marta Gut
- Martijn Beudel
- Martin Castelle
- Martin Chalumeau
- Martin P. Grobusch
- Martín Castillo De Vera
- Marwa Chbihi
- Marwa H. Elnagdy
- María Jesús Arranz
- María Soledad Holanda-peña
- Masato Ogishi
- Mateus V. Castro
- Mathilde Desvallées
- Matilde Valeria Ursini
- Matthew Cheng
- Matthew D. Wilkerson
- Matthieu Jamme
- Matthieu Schmidt
- Matthijs C. Brouwer
- Maude Bouscambert
- Maude Millereux
- Mayana Zatz
- Megan A. Cooper
- Mehdi Mezidi
- Mehdi Mirsaeidi
- Mehdi Oualha
- Melike Emiroglu
- Menno D. De Jong
- Michael J Ciancanelli
- Michael Lenardo
- Michael Levin
- Michael Levy
- Michael Thy
- Michel C. Nussenzweig
- Michela Botta
- Michiel Schinkel
- Michiel Van Agtmael
- Michèle Van Vugt
- Miguel Fernandez Arquero
- Mikko R. J. Seppänen
- Milica Mandic
- Minerva Cervantes-gonzalez
- Minh Khoi Le
- Miquel Alfonso Ramos
- Miranda F. Tompkins
- Mireia Bolivar-prados
- Mireille Caralp
- Mohamed Elgamal
- Mohamed Meghadecha
- Mohammad Shahrooei
- Mohammed F. Alosaimi
- Mohammed J. Uddin
- Mohammed Shahrooei
- Mohammed Zarhrate
- Monica Girona Alarcon
- Morgane Faure
- Muriel Fartoukh
- Murkesh Desai
- Mònica Girona-alarcón
- Nadhira Houhou
- Nadia Ettalhaoui
- Nadia Rivet
- Nadège Neant
- Nassima Si Mohammed
- Nathalie Gault
- Nathan Peiffer-smadja
- Nevin Hatipoğlu
- Niaid-usuhs/tagc Covid Immunity Group
- Nico Marr
- Nicolas Dauby
- Nicole Washington
- Niels Van Mourik
- Nikaïa Smith
- Noémie Mercier
- Noémie Vanel
- O. Chouchane
- Oksana Boyarchuk
- Oliver Sanchez
- Olivier Picone
- Olivier Terrier
- Oriane Puéchal
- Ouifiya Kafif
- Ozge Metin
- Ozge Metin Akcan
- Paolo Bonfanti
- Pascale Gaussem
- Patricia Bruijning
- Patrick Nitschke
- Patrick Rossignol
- Patrick Thoral
- Paul Bastard
- Paul Elbers
- Paul Kuentz
- Paul Quentric
- Pauline Manchon
- Pawel Zawadzki
- Peng Zhang
- Pere Soler-Palacín
- Peter K Gregersen
- Petter Brodin
- Philip Meade
- Philippe Jorens
- Philippine Eloy
- Pierre Morange
- Pierre Vabres
- Pierre-emmanuel Morange
- Pilar Ricart
- Père Clavé
- Qian Zhang
- Qiang Pan Hammarström
- Qinhua Zhou
- Quentin Le Hingrat
- Quentin Philippot
- Rabih Halwani
- Rafael Leon Lopez
- Rafaela González-montelongo
- Rana Hasanato
- Raphael Borie
- Rebeca Perez de Diego
- Recep Evcen
- Richard P. Lifton
- Robert Hemke
- Roger Colobran
- Romain Basmaci
- Romain Euvrard
- Romain Lévy
- Ruggero Capra
- Rui Yang
- Rutger Koning
- Sabina Kali
- Sabine M. Hermans
- Saeed H Al Turki
- Saleh Al Muhsen
- Saleh Zaid Al-muhsen
- Salma Jaafoura
- Samantha Shafer
- Sami Hraiech
- Samira Laribi
- Samuel D. Chauvin
- Samya Chakravorty
- Sandra Pellegrini
- Sandrine Couffin-cadiergues
- Sanne De Bruin
- Sara E. Vazquez
- Sara Espinosa
- Sarah E. Henrickson
- Sarah Tubiana
- Sarantis Korniotis
- Satoshi Kubo
- Satoshi Okada
- Selma Erol Aytekin
- Semra Calimli
- Sergio Aguilera-albesa
- Sevgi Keleş
- Sevket Arslan
- Sevtap Şenoğlu
- Seyed Alireza Nadji
- Shen-Ying Zhang
- Silvia Sánchez-ramón
- Simon J. Tavernier
- Simone Paghera
- Soizic Le Mestre
- Sophie Assant
- Sophie Durand
- Sophie Letrou
- Sophie Trouillet-assant
- Stanislas Lyonnet
- Stephanie Boisson-Dupuis
- Stephanie Dobbelaere
- Stephanie Hodeib
- Stijn Van De Velde
- Stuart Tangye
- Stuart Turvey
- Stéphane Dauger
- Stéphane Mouly
- Sukru Nail Guner
- Suzanne Geerlings
- Sylvie Behillil
- Sylvie Van Der Werf
- Sébastien Viel
- Taushif Khan
- Tayfun Özçelik
- Terese Auguet
- Theo Geijtenbeek
- Théo Trioux
- Tiffany Pascreau
- Timokratis Karamitros
- Tom Le Voyer
- Tom Maniatis
- Tom Reijnders
- Tom Van Der Poll
- Tomohiro Morio
- Trine H Mogensen
- Tristan Gigante
- Tristan Mirault
- Valentina Vélez-santamaria
- Valentine Piquard
- Valérie Vignali
- Vanessa Harris
- Vanessa Sancho-Shimizu
- Vassili Soumelis
- Ventzislava Petrov-sanchez
- Victoria Fumadó
- Vijay Sankaran
- Vincent Enouf
- Vincent Ve Enouf
- Vivien Béziat
- W. Joost Wiersinga
- Wahiba Frezouls
- Waleed Eldars
- Wesley Tung
- Willemke Stilma
- William M Schneider
- Xavier Duval
- Xavier Solanich Moreno
- Xijun Zhang
- Yacine Tandjaoui-Lambiotte
- Yahya Gul
- Yasemin Kendir Demirkol
- Yat Wah M. Kwan
- Yazdan Yazdanpanah
- Yee-sin Leo
- Yenan Bryceson
- Yeray Novoa Medina
- Yoann Schmitt
- Yoann Seeleuthner
- Yohann Schmitt
- Yolande Costa
- Yu Zhang
- Yu-lung Lau
- Yun Ling
- Yurdagul Uzunhan
- Yuri Stepanovskiy
- Yuval Itan
- Yves Lévy
- Zahir Amoura
- Zaven Terzian
- Zbigniew J. Król
- Zerrin Orbak
- Zhi Li
- Zhiyong Liu
- Zinan Zhang
- Şemsi̇ Nur Karabela
Organizations
- Aarhus University
- Agence Nationale de la Recherche
- Amsterdam UMC
- Assistance Publique – Hôpitaux de Paris
- Autonomous University of Barcelona
- Avicenne Hospital
- Bilkent University
- Columbia University
- Dasman Diabetes Institute
- French National Institute of Health and Medical Research
- Ghent University Hospital
- Hamad Bin Khalifa University
- Helix
- Howard Hughes Medical Institute
- Icahn School of Medicine at Mount Sinai
- Imperial College London
- Katholieke Universiteit Leuven
- King Abdulaziz Medical City
- King Abdullah International Medical Research Center
- King Saud University
- McGill University
- National Center for Advancing Translational Sciences
- National Human Genome Research Institute
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- Necker–Enfants Malades Hospital
- Necmettin Erbakan University
- New York Genome Center
- Pasteur Institute
- Sapienza University of Rome
- Shahid Beheshti University of Medical Sciences
- Sorbonne University
- St Giles Foundation
- Swiss Federal Institute of Technology in Lausanne
- The Rockefeller University
- UZ Leuven
- Uniformed Services University of the Health Sciences
- University College of Medical Sciences
- University of Antioquia
- University of Brescia
- University of Health Sciences
- University of Lausanne
- University of Milan-Bicocca
- University of Paris
- Université Libre de Bruxelles
- Yale University