Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes
Abstract
Most analyses of the antibody responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have focused on antibodies cloned from memory B cells. This approach has led researchers to conclude that neutralizing antibodies (nAbs) primarily target the receptor-binding domain (RBD) of the virus's spike protein. Voss et al. took a different approach, using proteomic deconvolution of the serum immunoglobulin G antibody repertoire from four COVID-19 convalescent patients. They found that the nAb response was largely directed against epitopes such as the N-terminal domain (NTD), which lie outside the RBD. Several of these nAbs were shared among donors and targeted an NTD epitope that is frequently mutated by variants of concern.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 04, 2021
- Source ID
- 10.1126/science.abg5268
Entities
People
- Andrew P. Horton
- Andrew S Herbert
- Brent L. Iverson
- Chelsea Paresi
- Chia-Wei Chou
- Dalton M. Towers
- Daniel Billick
- Daniel R. Boutz
- Dhwani Batra
- Foteini Bartzoka
- George Delidakis
- George Georgiou
- Gregory C Ippolito
- Ilya J Finkelstein
- Jan Pohl
- Jason J Lavinder
- Jason S. McLellan
- Jimmy D. Gollihar
- Jin Eyun Kim
- John M Dye
- Jonathan R McDaniel
- Jule Goike
- Justin Lee
- Kamyab Javanmardi
- Katia George
- Lori A. Rowe
- Maria D. Person
- Michelle Gadush
- Nianshuang Wang
- Nicole V Johnson
- Ralph S. Baric
- Shawn A Abbasi
- Shivaprakash Gangappa
- Suryaprakash Sambhara
- Whitney Pickens
- William N Voss
- Yixuan Hou
- Yuri Tanno
Organizations
- Centers for Disease Control and Prevention
- Houston Methodist Hospital
- National Cancer Institute
- National Center for Immunization and Respiratory Diseases
- National Institute of Allergy and Infectious Diseases
- Pfizer
- Robert A. Welch Foundation
- Tulane National Primate Research Center
- United States Army Medical Research Institute of Infectious Diseases
- University of California, San Francisco
- University of North Carolina at Chapel Hill
- University of Texas at Austin
- University of Texas at Austin College of Natural Sciences