Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study
Abstract
The severe acute respiratory syndrome coronavirus 2 spike protein is the basis of many vaccines and is a primary target of neutralizing antibodies after COVID-19 infection. The Coronavirus Immunotherapeutic Consortium (CoVIC), comprising 56 partners across the world, has analyzed a panel of 269 monoclonal antibodies (mAbs) and, on the basis of competition profiles, sorted 186 mAbs that target the receptor binding domain into seven communities. Hastie et al . went on to structurally analyze representative antibody binding and used pseudovirus neutralization assays to study the effect of spike mutations on antibody function, including the combinations of mutations found in certain variants of concern. These results are important to guide both treatment and prevention efforts. —VV
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 22, 2021
- Source ID
- 10.1126/science.abh2315
Entities
People
- Aaron K. Sato
- Adrian S Enriquez
- Ana González Hernández
- Andrew McGuire
- Anna J. MacCamy
- Anne Palser
- Bingqing Shen
- Bjoern Peters
- Chao Kong
- Cheolmin Kim
- Cheuk Lun Leung
- Chitra Hariharan
- Colin J Mann
- Covic-db Team
- Daniel H Bedinger
- David D Ho
- Dawid Zyla
- Diptiben Parekh
- Eduardo Olmedillas
- Elizabeth Feeney
- Erica Ollmann Saphire
- Fei Lan
- Georgia D. Tomaras
- Gevorg Grigoryan
- Gillian Q. Horn
- Guojun Lang
- Hanif Ali
- Haoyang Li
- Hyeong Mi Kim
- Jacob Glanville
- Ji-Min Seo
- Jian Yu
- Jieyun Yin
- John Ingraham
- Jonne L. Snitselaar
- Joseph M. Fernandez
- Junli Liu
- K. Li
- Kathryn M Hastie
- Kelly Shaffer
- Kuan-Ying A Huang
- Leonidas Stamatatos
- Liang Schweizer
- Marit J. van Gils
- Michelle A Zandonatti
- Milan Tomić
- Milite Abraha
- Minsoo Kim
- Mohammad M Sajadi
- Paul Kellam
- Q. Zhang
- Robin Green
- Rogier W Sanders
- Ronald R Cobb
- Ross S. Federman
- Ruben Diaz Avalos
- S Moses Dennison
- Sanja Aracic
- Sawsan Youssef
- Sean Hui
- Sharon L. Schendel
- Shelly J. Krebs
- Soo-Young Lee
- Terence Rabbitts
- Tierra K. Buck
- Timothy Germann
- Tom Z. Yuan
- Vamseedhar Rayaprolu
- Weidong Jiang
- Xiaoying Yu
- Yanan Lu
- Yoann Aldon
- Yongcong Tan
- Zahra Rikhtegaran Tehrani
Organizations
- Chang Gung University
- Columbia University
- Duke University
- Fred Hutchinson Cancer Center
- Fudan University
- Imperial College London
- Institute of Cancer Research
- La Jolla Institute for Allergy and Immunology
- Twist Bioscience
- University of Amsterdam
- University of California, San Diego
- University of Maryland
- Walter Reed Army Institute of Research