Bioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury
Abstract
Artificial scaffolds that bear the peptide-signaling sequences of proteins for tissue regeneration often have limited effectiveness. Álvarez et al . synthesized supramolecular peptide fibril scaffolds bearing two peptide sequences that promote nerve regeneration, one that reduces glial scarring and another that promotes blood vessel formation (see the Perspective by Wojciechowski and Stevens). In a mouse model of paralyzing human spinal cord injury, mutations in a tetrapeptide domain outside of the signaling regions improved recovery by promoting intense supramolecular motion within the fibrils. The mutation with the most intense dynamics resulted in corticospinal axon regrowth and myelination, functional revascularization, and motor neuron survival. —PDS
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 12, 2021
- Source ID
- 10.1126/science.abh3602
Entities
People
- Alexandra N Edelbrock
- Evangelos Kiskinis
- F. Chen
- Ivan R Sasselli
- Juan Alberto Ortega Cano
- Peter A Mirau
- Ruomeng Qiu
- Samuel I. Stupp
- Stacey M Chin
- Steven L Weigand
- Zaida Álvarez
- Zois Syrgiannis
Organizations
- Air Force Research Laboratory
- Northwestern University