Antigenic evolution of dengue viruses over 20 years
Abstract
Secondary Dengue virus (DENV) infections can be dangerous if levels of antibodies from prior infection are inadequate to clear the virus. This RNA flavivirus exploits the presence of lower levels of heterotypic antibodies to infect immunoglobulin Fcγ receptor–bearing cells. Many RNA viruses also exhibit antigenic variation, which classically allows evasion of immune responses. Katzelnick et al . investigated whether antigenic variation in DENV has a biological function in a virus that courts immune responses to enhance replication (see the Perspective by Rohani and Drake). Using antigenic cartography on a panel of more than 400 DENV1-4 subtype samples isolated in Bangkok, Thailand, the authors found that antigenic variation in virus populations oscillated between similarity and dissimilarity across subtypes over time, with outbreaks correlating with periods of antigenic dissimilarity within serotypes. This pattern may be at least in part a result of the conflicting evolutionary pressures of immune evasion and immune enhancement. —CA
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 19, 2021
- Source ID
- 10.1126/science.abk0058
Entities
People
- Ana Coello Escoto
- Angkana Huang
- Bernardo García-Carreras
- Butsaya Thaisomboonsuk
- Chris Chavez
- Derek Cummings
- Derek J Smith
- Gregory D. Gromowski
- Henrik Salje
- Irina Maljkovic Berry
- Leah C Katzelnick
- Louis R Macareo
- Nayeem Chowdhury
- Philippe Buchy
- Philippe Dussart
- Richard G Jarman
- Stefan Fernandez
- Stephen S Whitehead
- Veasna Duong
Organizations
- Armed Forces Research Institute of Medical Sciences
- GSK
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- Pasteur Institute
- University of Cambridge
- University of Florida
- Walter Reed Army Institute of Research