A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection
Abstract
Lipid nanoparticles containing mRNA encoding a human antibody for chikungunya virus protect against infection and arthritis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 24, 2019
- Source ID
- 10.1126/sciimmunol.aaw6647
Entities
People
- Aruna D De Silva
- Elisabeth Humphris-Narayanan
- Giuseppe Ciaramella
- Gopal Sapparapu
- James E. Crowe, Jr.
- Julie M. Fox
- Matthew A Theisen
- Michael S. Diamond
- Nurgun Kose
- Rashika N Tennekoon
- Robin Bombardi
- Sayda M Elbashir
- Sunny Himansu
Organizations
- Defense Advanced Research Projects Agency
- Moderna
- National Institute of Allergy and Infectious Diseases
- Vanderbilt University
- Washington University School of Medicine
- Washington University in St. Louis