TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes
Abstract
The SARS-CoV-2 virus infects cultured ACE2-expressing human enterocytes aided by the TMPRSS2 and TMPRSS4 serine proteases.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 19, 2020
- Source ID
- 10.1126/sciimmunol.abc3582
Entities
People
- Broc T McCune
- Harry B. Greenberg
- Kevin Brulois
- María Florencia Gómez Castro
- Matthew A. Ciorba
- Michael S. Diamond
- Naomi Sonnek
- Paul W Rothlauf
- Qiru Zeng
- Ruochen Zang
- Sean P J Whelan
- Siyuan Ding
- Xin Wang
- Zhuoming Liu
Organizations
- Defense Advanced Research Projects Agency
- Harvard Medical School
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institutes of Health
- Stanford University
- Stanford University School of Medicine
- United States Department of Veterans Affairs
- VA Palo Alto Health Care System
- Washington University School of Medicine
- Washington University in St. Louis