Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma
Abstract
Targeting a kinase common to both the EGFR and TNFα signaling pathways may prevent drug resistance in glioblastoma.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 12, 2014
- Source ID
- 10.1126/scisignal.2005196
Entities
People
- Andrea E. Errasti
- Anthony S. Perry
- Carla V. Rothlin
- Christopher Hulme
- Daniel Gibbs
- Edward K. Mandell
- Elisabeth J. Rushing
- Eugenio A. Carrera-silva
- Joseph C. Loftus
- Justin D. Dietrich
- Kenneth Aldape
- Michael E. Berens
- Nader Sanai
- Sourav Ghosh
- Weiwei Yang
- Yael Kusne
- Zhimin Lu
Organizations
- Arizona State University
- Armed Forces Institute of Pathology
- Barrow Neurological Institute
- Mayo Clinic Hospital
- The University of Texas MD Anderson Cancer Center
- Translational Genomics Research Institute
- University of Arizona
- University of California
- Yale University