PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion
Abstract
Cancer-associated mutations in PREX2 enable cells to overcome the tumor-suppressive effects of PTEN.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 31, 2015
- Source ID
- 10.1126/scisignal.2005840
Entities
People
- Barry Fine
- Benjamin D. Hopkins
- Cindy Hodakoski
- David Schoenfeld
- Douglas Barrows
- Hanina Hibshoosh
- Nicole Steinbach
- Ramon Parsons
- Sarah M. Mense
- Tao Su
- William Su
Organizations
- Columbia University
- Icahn School of Medicine at Mount Sinai
- National Cancer Institute
- United States Department of Defense