Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi
Abstract
Combining targeted CRISPR-mediated gene editing with an RNAi-mediated screen identifies candidate drug targets.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 08, 2015
- Source ID
- 10.1126/scisignal.aab3729
Entities
People
- Alexander J. Valvezan
- Bahar Yilmazel
- Benjamin E Housden
- Brendan D Manning
- Charles Roesel
- Colleen Kelley
- Michael Buckner
- Norbert Perrimon
- Richelle Sopko
- Rong Tao
- Shuailiang Lin
- Stephanie E. Mohr
- Yanhui Hu
Organizations
- Harvard Medical School
- Harvard T.H. Chan School of Public Health
- Howard Hughes Medical Institute
- National Cancer Institute
- National Institutes of Health
- United States Department of Defense