Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17
Abstract
Without the N terminus, iRhom proteins cannot properly limit ADAM17 activity, resulting in impaired cancer cell death.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 03, 2015
- Source ID
- 10.1126/scisignal.aac5356
Entities
People
- Aleksandra A. Pandyra
- Ananda A. Jaguva Vasudevan
- Astrid Evers
- Balamurugan M. Sundaram
- Carl P. Blobel
- Carsten Münk
- David P. Kelsell
- David R. McIlwain
- Dieter Häussinger
- Dorit Wolff
- Garry P. Nolan
- Jürgen Scheller
- Karl S. Lang
- Kazuhito Ohishi
- Matthew A. Brooke
- Nima Aghaeepour
- Philipp A. Lang
- Robin Polz
- Sathish K. Maney
- Tak Wah Mak
- Thorsten Maretzky
Organizations
- Alexander von Humboldt Foundation
- Canadian Institutes of Health Research
- Cancer Research UK
- Cornell University
- German Research Foundation
- Hospital for Special Surgery
- Medical Research Council
- National Institutes of Health
- Osaka University
- Queen Mary University of London
- Stanford University
- United States Department of Defense
- University Health Network
- University of Duisburg-Essen
- University of Düsseldorf