Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition
Abstract
Context-dependent kinase pathway cross-talk explains why p38 MAPK inhibitors are ineffective in patients with rheumatoid arthritis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 06, 2018
- Source ID
- 10.1126/scisignal.aal1601
Entities
People
- Anne P. Jenney
- Brian A Joughin
- Douglas A. Lauffenburger
- Douglas Jones
- Peter K. Sorger
Organizations
- Army Research Office
- Harvard Medical School
- Massachusetts Institute of Technology
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institute of General Medical Sciences
- Office of the Director