Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice

Abstract

Inhibiting the translation initiation factor eIF4E corrects neuronal behavioral phenotypes in a mouse model of fragile X syndrome.

Document Details

Document Type
Pub Defense Publication
Publication Date
Nov 07, 2017
Source ID
10.1126/scisignal.aan0665

Entities

People

  • Claudia Bagni
  • Edward Mojica
  • Emanuela Santini
  • Eric Klann
  • Francesco Longo
  • Laura D’andrea
  • So Yeon Koo
  • Thu N Huynh

Organizations

  • Columbia University
  • Congressionally Directed Medical Research Programs
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • Katholieke Universiteit Leuven
  • National Institute of Neurological Disorders and Stroke
  • New York University
  • Sapienza University of Rome
  • University of Lausanne

Tags

Fields of Study

  • Biology

Readers

  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Molecular Biology and Genetics