Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation
Abstract
Mutant RAS–selective dependence on the GEF SOS2 reveals tumor cell sensitivity to kinase inhibitors.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 04, 2018
- Source ID
- 10.1126/scisignal.aar8371
Entities
People
- Chenyue Wang
- Deborah K. Morrison
- Do Hyung Kim
- Elizabeth Lee
- Elizabeth M. Terrell
- Erin Sheffels
- Isabella A. Vazirani
- Ji Luo
- Nancy E Sealover
- Robert L Kortum
Organizations
- Congressionally Directed Medical Research Programs
- National Cancer Institute
- Uniformed Services University of the Health Sciences