The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling
Abstract
A bacterial toxin effector domain disrupts RAS-ERK signaling by cleaving RAS through an unusual mechanism.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 02, 2018
- Source ID
- 10.1126/scisignal.aat8335
Entities
People
- Alfa Herrera
- Andrew G. Stephen
- Avik Banerjee
- George Minasov
- Karla Satchell
- Lakshman Bindu
- Marco Biancucci
- Maria Abreu-blanco
- Matthew B Kieffer
- Matthew Holderfield
- Patrick J Woida
- Vadim Gaponenko
- Wayne F. Anderson
Organizations
- Leidos
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Northwestern University
- Pancreatic Cancer Action Network
- Robert H. Lurie Comprehensive Cancer Center
- United States Department of Defense
- University of Illinois at Chicago