Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability

Abstract

Loss of DNA demethylase TET2 protects stalled replication forks from degradation and confers chemoresistance.

Document Details

• Document Type: Pub Defense Publication
• Publication Date: Aug 18, 2020
• Source ID: 10.1126/scisignal.aba8091

Entities

People

• Akshey Suresh
• Chinmayi Pamala
• Divya Swaminathan
• Eugen Buehler
• Hanna Marks
• Kathrin Muegge
• Manish Singh
• Sandra Burkett
• Satheesh K. Sengodan
• Scott E. Martin
• Shyam K Sharan
• Stephen D Fox
• Suhas Kharat
• Xia Ding
• Yafeng He

Organizations

• National Cancer Institute
• National Institutes of Health
• United States Department of Defense