Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1
Abstract
DGKα inhibition restores apoptosis in SAP-deficient lymphocytes, decreasing immunopathology in XLP-1 patients.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 13, 2016
- Source ID
- 10.1126/scitranslmed.aad1565
Entities
People
- Andrea Graziani
- Andrew L. Snow
- Christoph Biskup
- Christoph Wülfing
- Cosima T. Baldari
- Elisa Ruffo
- Gianluca Baldanzi
- Ignacio Rubio Scola
- Katherine Verbist
- Kim E. Nichols
- Laura Patrussi
- Paige Tedrick
- Pamela L. Schwartzberg
- Rupali Das
- Sasha E. Larsen
- Senta M. Kapnick
- Valeria Malacarne
Organizations
- Fondazione Compagnia di San Paolo
- Jena University Hospital
- Michigan State University
- National Human Genome Research Institute
- National Institutes of Health
- St. Jude Children's Research Hospital
- Telethon Foundation
- Uniformed Services University of the Health Sciences
- University of Bristol
- University of Siena