Triple-negative breast cancers with amplification of JAK2 at the 9p24 locus demonstrate JAK2-specific dependence

Abstract

JAK2 amplification decreases survival in triple-negative breast cancer but can be targeted with JAK2-specific inhibitors.

Document Details

• Document Type: Pub Defense Publication
• Publication Date: Apr 13, 2016
• Source ID: 10.1126/scitranslmed.aad3001

Entities

People

• Carlos L Arteaga
• Daniel Dávila-gonzález
• David L Rimm
• Donna Hicks
• Franco D. Doimi
• Henry Gomez
• Jennifer M Giltnane
• Jenny C. Chang
• Joseph A. Pinto
• Justin M. Balko
• Kai Wang
• Luis J. Schwarz
• Melinda E. Sanders
• Melissa D. Landis
• Monica V. Estrada
• Na Luo
• Phillip J. Stephens
• Phillip T. Dean
• Rebecca S. Cook
• Roman Yelensky
• Susan E. Combs
• Vincent A. Miller
• Violeta Sanchez

Organizations

• Bristol-Myers Squibb
• Foundation Medicine
• National Cancer Institute
• United States Department of Defense
• Vanderbilt University
• Vanderbilt-Ingram Cancer Center
• Yale University