Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

Abstract

MMV390048, a member of a new class of inhibitors of the Plasmodium phosphatidylinositol 4-kinase, shows potential for both treatment and prophylaxis.

Document Details

Document Type
Pub Defense Publication
Publication Date
Apr 26, 2017
Source ID
10.1126/scitranslmed.aad9735

Entities

People

  • Anchalee Tungtaeng
  • Andrea Ruecker
  • Andrew M. Blagborough
  • Anne-marie Zeeman
  • Brice Campo
  • Chek Shik Lim
  • Christian Scheurer
  • Christophe Bodenreider
  • Claire Le Manach
  • Clemens H. M. Kocken
  • Cristina Donini
  • David A. Fidock
  • David M. Shackleford
  • David Waterson
  • Didier Leroy
  • Diego González Cabrera
  • Francisco Javier Gamo
  • Gerard Drewes
  • Iñigo Angulo-Barturen
  • Janette Reader
  • Janne Mannila
  • Jeremy Burrows
  • Julia Morizzi
  • Karen L. White
  • Kelly Chibale
  • Kennan C. Marsh
  • Kirsten K Hanson
  • Koen J. Dechering
  • Laura María Sanz
  • Leslie J Street
  • Lyn-marie Birkholtz
  • Marcus Bantscheff
  • Marcus C. S. Lee
  • Mariette Botha
  • María Belén Jiménez-díaz
  • María José Lafuente-monasterio
  • María Santos Martínez
  • Michael J. Delves
  • Michael J. Witty
  • Pattaraporn Vanachayangkul
  • Philipp P. Henrich
  • Rajshekhar Basak
  • Robert W Sauerwein
  • Rosemary Rochford
  • Santiago Ferrer
  • Sara E. Zakutansky
  • Sergio Wittlin
  • Sonja Ghidelli-disse
  • Suresh M Solapure
  • Susan A. Charman
  • Tanya Paquet
  • Tara S Abraham
  • Yassir Younis

Organizations

  • AbbVie
  • Armed Forces Research Institute of Medical Sciences
  • Biomedical Primate Research Centre
  • Columbia University
  • GSK
  • Imperial College London
  • Jackson Laboratory
  • Medicines for Malaria Venture
  • Monash University
  • National Institutes of Health
  • Radboud University Medical Centre
  • Swiss Tropical and Public Health Institute
  • Thomas Jefferson University
  • TropIQ Health Sciences
  • University of Basel
  • University of Cape Town
  • University of Colorado Denver
  • University of Pretoria
  • University of Texas at San Antonio
  • Wellcome Sanger Institute
  • Wellcome Trust
  • Yale University

Tags

Fields of Study

  • Chemistry
  • Medicine